Ciprofloxacin: an oral quinolone for the treatment of infections with gram-negative pathogens. Committee on Antimicrobial Agents. Canadian Infectious Disease Society. Gram‐positive spore‐forming rods are frequent contaminants of cultures but may cause serious infections such as septicemia, endocarditis, endophthalmitis and wound infections. Bacillus cereus, the most frequent species, is resistant to β‐lactam antibiotics [ 4 ]. Ciprofloxacin Antibiotic Class: Quinolone Antimicrobial Spectrum: Gram-positive: methicillin-susceptible Staphylococcus aureus (MSSA) (lowest quinolone With the recent introduction of agents such as gatifloxacin and moxifloxacin, the traditional gram-negative coverage of fluoroquinolones has been expanded to include specific gram-positive organisms. Infecting Organism. Medication of Choice. Alternative Medications. I. AEROBIC BACTERIA: A. Gram Positive. 1. Staphylococci a. Non-penicillinase producing 1. Am J Med. 1987 Apr 27;82(4A):27-32. In vitro activity of ciprofloxacin against gram-positive cocci. Barry AL, Jones RN. In vitro studies compared the activities of ciprofloxacin, vancomycin, and fusidic acid against staphylococci, streptococci, and enterococci. Spectrum: Good gram positive (although possibly worse than 1st generation) and excellent gram negative coverage (E.coli, Proteus, Klebsiella, Neisseria, H.influenza, and most SPACE organisms, but not Pseudomonas), no anaerobes. Increased Gram Positive coverage (including MRSA) over other Quinolones However, should be reserved for resistant infections refractory to other agents (2017) Presc Lett 24(11): 66 INTRODUCTION. The fluoroquinolones have been a popular class of antibiotics for use in a variety of infections. Newer drugs in this class have been developed with a broader spectrum of activity including better coverage of gram-positive organisms and, for some fluoroquinolones, anaerobes. Ciprofloxacin is particularly effective against Gram-negative bacteria (such as Escherichia coli, Haemophilus influenzae, Klebsiella pneumoniae, Legionella pneumophila, Moraxella catarrhalis, Proteus mirabilis, and Pseudomonas aeruginosa), but is less effective against Gram-positive bacteria (such as methicillin-sensitive Staphylococcus aureus, Streptococcus pneumoniae, and Enterococcus.